1201: Benjamin Bikman | Insulin Resistance Is Killing Half of America

1201: Benjamin Bikman | Insulin Resistance Is Killing Half of America

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Dr. Benjamin Bikman: no one is sitting around craving a plate of bacon and eggs. It doesn't happen. They're not wanting a stick of butter to be chomping on while they're watching a show on a Friday night.

They want carbs. Carbs are the one macronutrient that humans crave and dare I say, have addictive tendencies towards, based on many conventional definitions of addictive behavior. They seek it, they crave it, they regret it. When they over, they can't moderate it. Is all these aspects of addiction.

Jordan Harbinger: Welcome to the show. I'm Jordan Harbinger. On The Jordan Harbinger Show, we decode the stories, secrets, and skills of the world's most fascinating people and turn their wisdom into practical advice that you can use to impact your own life and those around you. Our mission is to help you become a better informed, more critical thinker through long form conversations with a variety of amazing folks, from spies to CEOs, athletes, authors, thinkers and performers, even the occasional Russian chess [00:01:00] Grandmaster Emmy, nominated comedian, extreme athlete, or tech luminary.

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Just visit Jordan harbinger.com/start or search for us in your Spotify app To get started, my guest today has published over 150 peer reviewed papers, runs an NIH funded lab, and has a PhD in something called bioenergetics, which let's be real, sounds a lot less like science and more like something you'd pay 3 99 for it, a weekend chakra alignment retreat, but I promise it's the real deal and here's why you should care.

He argues that it's not sugar itself that's driving modern disease. It's insulin, this blood sugar hormone that's actually kind of the boss of your entire metabolism. Half of the adults in the US already have insulin resistance, most don't even know it. It's quietly wrecking everything from your heart to [00:02:00] your hormones, to your brain.

And today we're digging into what insulin really does, how it can tank your health before you even know what's going on. Why my pants don't fit slash I can't see my, you know what, without a mirror is not the only symptom to watch out for. And most importantly, what you can actually do to fix it before you end up as another scary statistic.

Alright, here we go with Dr. Benjamin Bickman. Look, I have to say I was skeptical first about having you on, 'cause you got a, you got a PhD in something called bioenergetics, which first of all sounds like Scientology or something that involves chakras.

Dr. Benjamin Bikman: So, so I, there is, in fact that term has been hijacked, I'm sure by kind of guru spiritual wellness individuals where it really is like harnessing the energy like chakra in your body.

Yeah. And it's pretty discouraging. Uh, I put my head in my hands when I hear that,

Jordan Harbinger: but in fact, by all means, let me define it. Yeah, please. 'cause I don't think anybody knows what it is. I, I think most people are gonna go, oh, I've heard of this. It's, uh, you know, getting energy from the earth while you meditate [00:03:00] or something.

Right? Yeah. Nobody knows. Right, right. The real version. Yeah.

Dr. Benjamin Bikman: So it's a very niche area within science, in fact. When I earned that PhD in bioenergetics, there were only three universities in the entire country. Uh, in fact, I think only two at the time. Actually, now there's three that even offered a degree in bioenergetics.

So bioenergetics is a bit of a hybrid degree where it's a combination of a lot of biochemistry and physiology. So physiology is the study of how the systems in the body work. And then of course, biochemistry is the reactions within the cell that allow the cell to live. And then bioenergetics is a bit more of a heavy emphasis on the mitochondria, which is the powerhouse, the energy producing part of the cell.

And so it's kind of this, well, it is a hybrid, but a, an amalgamation of looking at energy in a very biochemical sense, which is things like calories, nutrients, how you burn things, how you build things. And that is all within the context of biology and the cell. So you take the chemistry [00:04:00] part, the biochemistry.

Then integrated into, well, what does this mean in the context of things like obesity and diabetes?

Jordan Harbinger: It sounds like from the book I read, why we get sick, it sounds like you frame insulin and not glucose as this sort of upstream driver of almost every, what's the word, cardiometabolic disease from type two diabetes to some cancers.

Is that a fair summary?

Dr. Benjamin Bikman: Yeah, it is. Yeah. So that's a view that I believed and still do was sufficiently poorly understood that someone needed to kind of harness that message and encapsulate it. While I love academia, I also get frustrated by the limits we place on ourselves, which is we're content to just know something because we think the knowledge itself has value and we can't be bothered to wonder whether the idea actually has some legs to it in the real world.

But yeah, I attempted to articulate those points in the book. But again, as you stated, the central premise of this is that as much as we have a glucose centric. Paradigm of metabolic health. You know, you go in and get a blood test every time [00:05:00] they're measuring glucose or your hemoglobin A1C, they will never measure insulin.

So our obsessive focus in zeroing in on glucose actually has us missing the more important marker. Because if we can reframe the paradigm to focus, or at least include insulin, we not only detect these cardiometabolic chronic diseases much, much sooner, but we also treat them much better.

Jordan Harbinger: We used to get sick from infectious diseases, right?

Cholera and all these. Well, now they're kind of, we're getting a resurgence of some of this, but mostly, more or less, this isn't true anymore. I'm not worried about my kids getting dysentery like the Oregon Trail. That's not gonna happen. Now people are getting sick and dying from what is called metabolic disease.

So tell us what this is, because unfortunately the word metabolism has also been sort of hijacked by the fitness and wellness people, where it's like, you gotta eat this to get your metabolism going. And my trainer's like, dude, your metabolism has not stopped because we are, you are not dead on the floor.

That's when your metabolism stops. You don't need to eat broccoli or superfood or drink this [00:06:00] kind of thing to get your metabolism going. And metabolic disease doesn't mean you're not digesting food, right. It's totally different. So tell us what this actually means

Dr. Benjamin Bikman: now. That's a really, really good question.

Particularly right now, while we are enjoying a moment where a lot of public health professionals at high levels are talking about metabolic health, quote unquote. So I think it is in our best interest to make sure we have a common definition of that term, because metabolism does mean, it almost means whatever a person wants it to mean.

There are as many different definitions of metabolism as there are people to invoke the term. So as a scientist, within the realm of metabolic research, I think the most apt definition is actually one that your trainer is alluding to, which is that metabolism is the sum of all chemical reactions happening in a cell at any moment.

And then it is defined. You can then one layer down, break metabolism in all metabolic reactions up into two categories. Anabolic reactions, those reactions that are building up molecules, and then catabolic [00:07:00] reactions, those biochemical reactions that are breaking things down. Now, even still with that definition, someone could say, well, what does that have to do with metabolic health?

Right? So here's where I think the best definition comes in. In fact, let's think sort of down two steps. I think it'd be easy for someone, if we could all agree, we would say, okay, the maybe simplest definition is to look at it through the lens of the metabolic syndrome. After all, they both have the word metabolic in them, and the metabolic syndrome is this cluster of complications that always clumps together.

Things like elevated waist circumference, elevated blood glucose, elevated blood pressure, and then dyslipidemia your blood lipids, your triglycerides and your HDL are a little out of whack.

Jordan Harbinger: Did you say elevated waist circumference? That is, yeah. That is the best PC term for being fat that I've ever heard.

Yeah. Yeah, yeah,

Dr. Benjamin Bikman: yeah. But I do need to emphasize that it is specific to that middle of the body. I see. You know, it's that truncal fat, and so that's why I have to just point it out a little bit more than just saying, you're chubby because where you hold fat matters [00:08:00] tremendously. So that's the metabolic syndrome.

But then even still, someone could say, but why are all those metabolic? What do they all have to do with each other? That's where I think we take it down to the final foundational layer, which is what we call the metabolic syndrome, used to be called the insulin resistance syndrome, and now we've actually come to the cause of it all.

If we can say metabolic health, but be thinking, what is your insulin resistance status? Now we are really talking about some productive terms.

Jordan Harbinger: Okay, so this is maybe not what kills us, but this is what makes us sick. And then somebody comes in and says, oh, cardiac arrest due to high blood pressure. And you're saying, okay, they put a period at the end of that.

But what I, it sounds like what you're saying is cardiac arrest due to high blood pressure do due to insulin related resistance and the chain reaction of things that happens when that's elevated for, I don't know, like 30 years or something.

Dr. Benjamin Bikman: That's exactly right, Jordan. Yeah, you nailed it. Where I would say, and again, this does have real world ramifications because if the [00:09:00] clinician simply says to the patient, you have high blood pressure.

Then if it stops there, if there is a period as you said, then the next sentence is, and here's your prescription for a drug. Right? If, however, address this symptom. Yeah, yeah, exactly. If we say you have high blood pressure, comma, which is a consequence of insulin resistance, period. Now the next sentence is in response to maybe the patient's question, what do I do about it?

Okay, well this is a lifestyle problem. Yeah. So now we start to change your lifestyle, and that's why you see so consistently blood pressure drops so quickly as a person just directly makes lifestyle changes to improve their insulin resistance.

Jordan Harbinger: So when I was 33, I had 39% body fat, I think, which is not good.

For those of you keeping track at home, that's not good. Right now I have 12 and most people wouldn't say, you're so skinny, put some meat on. Right. I just look like a normal person. So I had 38, 30 9% body fat. And the doctor I went to one of those like CEO health checks where they have you running on a treadmill and they take blood work, it takes like eight hours.

You know, they're doing all the scans [00:10:00] and the guy was like, your blood pressure's high, your insulin resistant. It's called pre-diabetic or whatever. And he's like, but it's not quite pre-diabetic. It's like pre, pre-diabetic. But bear in mind again, I was 33 at the time and I said, oh, I have a prescription for blood pressure medication that I just got from my doctor.

And this guy goes, look, I'm not your doctor. I am a doctor. You really should not be taking that for the next 50 years of your life. He's like, what you should do is get in shape, because if you lose a bunch of weight and you start eating right, your insulin resistance is gonna go down. And I bet, um, and even though it's genetic, you know, partly your blood pressure is also gonna go down and you probably don't actually need it.

You're just fat. And he is like, I'm not trying to be mean. You know, he basically was just like, look, get a second opinion, please. Again, I'm not your doctor. But I took it to heart. I got, I went out a diet, I got a trainer. I didn't do it right away, which I should have, but I lost 50 plus pounds of fat. I got in really good shape, and I do measure my blood pressure every day.

I went from high blood pressure to completely normal blood pressure. I went from insulin super high, insulin, what, what was it called? A1C, the thing you mentioned [00:11:00] earlier that was like off the charts bad. Now it's really good. My cholesterol was like 150, now it's 75, 1 of one of 'em. Triglycerides, I think.

And all of the bad numbers became good just because I stopped eating as much and I got into shape physically. It, it's hard to sort of overstate how much you can fix with lifestyle because you're hitting that downstream effect that you mentioned. Right? You're getting, you're managing the insulin, so the blood pressure, the cardiac arrest, the brain, all this stuff is just like, it doesn't have a chance to develop.

It's downstream. Yeah. It's downstream. It's downstream,

Dr. Benjamin Bikman: as you said. Yeah. If we can drill down to the base foundation and say, sometimes we'll use the analogy of a tree where chronic disease nowadays and medicine is like a a tree where we are looking at each little branch of this diseased tree and we're saying, Jordan, you have high blood pressure, so we're gonna just trim off these little branches with a blood pressure medication.

Or maybe you've got erectile dysfunction, we're gonna trim it, that little branch, and here's a medication. And we're never actually just looking at the whole tree and say, why don't we just chop the whole thing down? So when we can acknowledge that all of these are simply [00:12:00] branches off of one, same core or truncal problem, namely insulin resistance.

And that allows us to actually address the cause rather than the symptoms.

Jordan Harbinger: I like this. Unfortunately. I also read in your book that insulin resistance is one of the most common conditions worldwide, which is scary. And I'll say scary rights because now you have to tell us what insulin resistance is.

'cause I'm not sure I actually know. Yeah. What it means. I know a lot of people listening certainly don't. But if this is one of the most common conditions worldwide and it's bad, tell us what it is and how it causes other diseases.

Dr. Benjamin Bikman: Yeah, of course. That's great. Yeah. So insulin resistance is a pathology with two parts.

So there's two aspects to this disease. There's two sides to the coin. There's the one side which gives us the term itself, which is the fact that in the body, some cells are not responding well to insulin, so they become resistant to insulin's signal.

Jordan Harbinger: Okay? So it tells other things what to do in your body.

That's a

Dr. Benjamin Bikman: perfect description, okay? That's what hormones do. Hormones are simply messages that are sent from the body telling the cells what to do, and every cell. [00:13:00] Importantly, this does matter. Every single cell of the body has insulin receptors on it. These little docking stations that are specific for insulin to come and dock and then tell the cell to do something.

But again, with insulin resistance, some cells aren't working particularly well, but then that's one half of the problem. When we flip the coin over this one coin that I'm calling insulin resistance, we have to consider the other part of this, which is that within the body, blood insulin levels are much higher than they were before.

So that's a condition called hyper insulinemia. So insulin resistance is two things. One insulin isn't quite working well, and then second insulin levels are much higher. That two part definition is critical to understand how insulin resistance as a collective term can create so many different pathologies where it is, how can it contribute to Alzheimer's disease and atherosclerosis and hypertension and infertility [00:14:00] in both male and female, et cetera.

We have to keep both definitions in mind. But one other part of this, when we look at the global level, let me just really put a fine point on that. I was actually invited to do my, what's called a postdoctoral fellowship in Singapore of all places. So after I finished my PhD in bioenergetics in North Carolina, I knew I wanted to continue to pursue science and have the life of an academic.

As a good means to an end to provide for my family. It was a job that I wanted, and so to do that, getting a PhD is not enough. You have to do something called a postdoctoral fellowship. I did mine in Singapore with the Duke Medical School. Now, of course, duke has an elite medical school. They partnered with the government of Singapore to create a very high level elite medical school with a heavy emphasis on metabolism research like diabetes and type two diabetes is the most obvious outcome of insulin resistance.

You think [00:15:00] about insulin and its main job controlling blood sugar. Well, when insulin's not working well, blood sugar goes up, and now you've got type two diabetes. But in Singapore, this beautiful country in Southeast Asia, one of my children was born there. We love it there. We just went there for spring break this year.

We love it. Interestingly, you walk on the streets of Singapore and you would look at the average Singaporean of predominantly East Asian descent, so Chinese descent primarily. You'd be surprised at how few chubby people there are. Maybe they're a little chubby. Someone's a little chubby. But you walk on the streets of the United States with, uh, blacks and whites being the primary ethnicities, and we have a lot of obesity here.

Jordan Harbinger: Yeah.

Dr. Benjamin Bikman: And yet, as much as we are as a country fatter than Singapore, we have less insulin resistance and less type two diabetes than they do what? Yeah. As a percent of the population. Wow. The United States, when it comes to type two diabetes as a formal diagnosis. We are about country number 70 or so.[00:16:00]

Whereas Singapore has been as high as number nine. I think they might be in the low teens right

Jordan Harbinger: now. So it's not just about being fat. It's

Dr. Benjamin Bikman: not just about being fat. That's a, I don't wanna force the conversation too early into the origins of insulin resistance, but how we store fat actually matters much more than how much fat we're storing.

Jordan Harbinger: Okay. I wanna get to that in a little bit because I, I do find that's super interesting. I wouldn't have expected that. However, if you go to China, you'll see a lot of fat people. I was shocked. I was thinking like you guys, we gave you Kentucky Fried Chicken, but you gotta use it responsibly. What is going on here?

It, it's start starting to look like Michigan over here. Come on. Yeah. And in

Dr. Benjamin Bikman: fact, no surprise, no surprise that they have higher rates of type two diabetes than we do.

Jordan Harbinger: Look, I, I probably am a little bit biased 'cause I live, I, I have a skew, right? I live in California and so people are like, I, I don't know anybody that buys Frappuccinos for example.

I'm sure obviously a lot of people do that. But I don't know people that drink Slurpees. But in, in China and in Asia, like you go and you get a bubble tea, you know those boba teas and you go, oh, okay. And if you forget to [00:17:00] say no sugar, it is like a 100% saturation of sugar in milk tea. And you just feel your teeth like dissolving with every sip.

It's worse than Coca-Cola. And people will drink and eat treats like that constantly. And you, my wife who's uh, who's East Asian from Taiwan, she goes, yeah, but you don't see any fat people. It's gotta be genetic. And it sounds like what you're telling me is it doesn't matter if they're fat, they're still all sick with the same stuff you get even if you're fat.

Dr. Benjamin Bikman: Yeah. Some ethnicities simply have a potential to get fatter. And again, I don't wanna pull us into that too soon. Uh, but some ethnicities like blacks and whites, for example. As different, as many people would claim, we are as ethnicities. One thing we have in common is that we make more fat cells more easily than many other ethnicities do, and that gives us this paradoxical situation where in blacks and whites and all, all ethnicities are on the spectrum, where on one end we have blacks and whites.

We make fat cells more readily than most other ethnicities, but because of that, all of the [00:18:00] fat cells we have are smaller, and that's where the rubber meets the road. It's the size of the fat cell that matters, not the massive fat. Then on the other end of that spectrum, you have people like of East Asian ethnicity where they have a very limited potential to make new fat cells, so any fat that they're gaining is forced to be stored in fat cells that are getting increasingly or ever larger in volume.

The technical terms are hypertrophy when it comes to fat cells getting bigger because we aren't making new ones versus hyperplasia where you're making new fat cells, which means, again, the paradox being you actually have the potential to store a lot more fat because you can just keep making new fat cells.

But the result of that is that the fat cells are much smaller and small. Fat cells are not only insulin sensitive, they're also actually anti-inflammatory, which helps with the overall health profile of the person. So here, the United States is a good example, although we are not even the fattest country on the planet.

Thank you very [00:19:00] much. We're neither the fattest nor the dumbest, nor the most diabetic and defensive, the, are you sharing United States? I wanna see the notes. Yeah. I know it's surprising to see the data, but, but we are, we are fat. Yeah. Um, but we are healthier than other countries that are much less fat.

And again, it's because we have more but smaller fat cells than East Asians, south Asians, Hispanics, they're all on that other end of the spectrum of having a limited potential to make new fat cells. And so a little bit of fat. If you take a, an East Asian version of me and you, you put 10 pounds on that version of us and versus 10 pounds on this European version of us, the European version.

We just don't look as good in our Speedo, the East Asian version, we've got pre-diabetes and hypertension.

Jordan Harbinger: Oh, I see. So the bar for them to have the same problems with the same level of fat, it sounds like it's lower.

Dr. Benjamin Bikman: That's a perfect metaphor because what the term that is often used when I actually teach this as a lecture, I use the term personal fat threshold.

Yeah, yeah. And I actually animate [00:20:00] in a little bar on a body and say, you know, so a person with a very low fat threshold, that'd be like the East Asian body where a little bit of fat and you're already, you've already gone too far. But the bar on the northern European body is much, much higher. So you can have a lot more fat before you reach that critical threshold where it starts to become a problem.

Jordan Harbinger: That makes sense. 'cause when I was 40% body fat, I had problems. But when I was probably like 35 or 32% body fat, my blood work still looked okay. You know, I looked chubby, but it was like, unfortunately most of it was visceral. So between my organs. So I carried it really well and people would always say, there's no way you lost 50 pounds.

'cause I bare. I didn't really look that different. Yeah. But my organs were like, ah, I can move in here again. Oh my gosh, I can breathe. Thank you. Right. I mean, they were just getting crushed by fat between all of my or, which is, I guess what raises blood pressure, right? When something's getting, there's a frigging balloon full of fat between each of your organs pushing on everything.

Yeah.

Dr. Benjamin Bikman: Visceral, visceral fat cells are actually more problematic than subcutaneous fat [00:21:00] cells. So the human body will primarily store fat in two depots. Subcutaneous, which is the fat that we can jiggle and pinch, that's the right beneath the skin. And that has a potential to grow out. And so if you are having more fat stored subcutaneously, you're making more fat cells.

'cause you can just keep pushing it out. Visceral adipose, because of the volume limit, will only grow through hypertrophy. So 10 pounds of visceral fat will have a much greater consequence on health than 10 pounds of subcutaneous fat. Because those visceral adipocytes will not grow through hyperplasia.

They will not multiply because then you begin to physically compress too much.

Jordan Harbinger: Yeah.

Dr. Benjamin Bikman: So they become very hypertrophic, which promotes insulin resistance and inflammation and the way they contribute to blood pressure. That the more you're increasing insulin, the more you're actually forcing the kidneys to retain salts and water, which just increases blood volume, which in turn increases blood pressure.

Jordan Harbinger: I see. Yeah. This is interesting, and this is one of the reasons why, now that I'm in shape, one of the reasons I [00:22:00] I wanna stay in shape forever is because I look and feel good. But two, I realize that my personal fat threshold, even for I guess a white person, is a little bit lower because my genetics are, Hey, let's store all of this between your organs before we start making your waistline bigger.

Whereas like other folks in, even in my own family, they'll get a huge belly, but they're, nothing changes because their fat is all in the front or the sides. They get love handles.

Dr. Benjamin Bikman: That's absolutely true. So that's an important point where even within the same ethnicity, you can have a tremendous variance, but also it explains the difference between sexes.

Hypertrophy also explains within the same ethnicity why females are invariably fatter than males and healthier at the same time. If it was just a matter of fat mass, every woman would be sicker than her male counterpart with cardiometabolic problems, because females are naturally fatter due to sex hormone differences, but they're not, because females, again, because of sex hormones like estradiol will start to [00:23:00] not only store fat subcutaneously more than men, but also activate more fat cell growth as needed.

And so they'll stimulate the creation of new fat cells. So women will be fatter than men, but because they have more but smaller fat cells, they will invariably be more protected against these cardiometabolic problems that come from insulin resistance.

Jordan Harbinger: So what are the maybe top three lifestyle factors that spike insulin all day long?

Are we talking about like meal timing or ultra processed foods and weird stuff that we're eating and or carbs? What's the villain here?

Dr. Benjamin Bikman: Yeah. Yeah. Right. Yeah. So that question touches on what are the kind of cardinal causes of insulin resistance. I believe that there are three actually worth noting. I will mention them in order of, of increasing importance.

Two causes are relevant, but they're also things that you can't control too readily, which is stress and inflammation. Stress. And I define that as a professor who teaches endocrinology. So a [00:24:00] class in hormones, stress is really defined by the elevation of the two primary stress hormones, adrenaline. In the US we call it epinephrine, actually, epinephrine and cortisol.

So those two hormones, when they're up, they will promote insulin resistance. But there's only so much you can do. You know, like if someone says, well, my cortisol's up, what can I do? We'd say, well, calm down. And they'd say, well, now I'm even more stressed because I can't calm down. I, you know, so as much as it's a variable, it's also one you can't really, it's a lever you can't really control very well.

The next one is inflammation. Inflammation causes insulin resistance. But again, that's a slippery lever. You can't really move it very well. It depends on some variables that may be outside of your control, but thankfully, both of those are more modest than the main one, which is the one you ask the question with, which is insulin itself.

A fundamental feature of biology is the, too much of something will generally result in a resistance to that something. And then that brings us to insulin. If we are living a, a lifestyle [00:25:00] and eating a diet that is constantly raising our insulin, the body starts to become resistant to that signal. And then what we then can logically just come to the conclusion of asking what, what spikes insulin the most?

And that's of course, starches and sugars. So refined carbohydrates. I point the finger solidly at that as the primary culprit that we have a culture of not only eating all the time and drinking. In the case of like the bubble tea, it's a perfect example. Where we eat and drink refined starches and sugars almost all day.

Certainly, as far as insulin is concerned, it is all day because it will take insulin anywhere from three to four hours to come down after someone's had a big carb heavy meal. The average individual worldwide at this point, from the Middle East to East Asia to Southeast Asia to North and South America, through Europe and everywhere, the average individual spends every waking moment in a state of elevated insulin.

Insulin has come down overnight. [00:26:00] Just to put all this in perspective, overnight, we've been fasting just because we've been asleep. Ideally, we wake up in the morning and the global first thing in the mouth is going to be something sugary and starchy. Again, it doesn't matter where you are, that's become common, and so we spike our insulin and then a couple hours later we do it again with a mid-morning snack.

We do it again more dramatically with a big lunch and in an afternoon snack, and then a dinner, and then of course we need a snack or two in the evening. So it is several hours into our sleeping moments before insulin finally comes down. And so that's why I say insulin matters more than the other variables, but then it matters even more because it's also one that you can immediately start to change by just cutting out those carbs.

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And the course does all of that in a very easy, non cringey, down to earth way. There's no awkward strategies or cheesy tactics. It's all practical stuff that'll make you a better connector, a better colleague, a better friend, a better peer. And six minutes a day is all it takes. Many of the guests on the show to subscribe and contribute to the course.

Come on and join us. You'll be in smart company where you belong. You can find the course again all free@sixminutenetworking.com. Alright, now back to Dr. Benjamin Bickman. Let's say that we get blood work done pretty regularly for Americans, which is what? Annual or something if that. Right? I do it every probably 10 weeks, but that's because I'm terrified of death.

But, uh, uh, and also because I, I spent my whole life not [00:30:00] caring and not paying attention and now I'm trying to make up for lost time and I'm experimenting with things, but that's neither here nor there. But so from my point is most of us are not paying attention to this stuff. Or we get blood work and our doctor goes, looks fine.

And you go, alright. You don't really know that he meant looks fine for a 60-year-old man even though you're 24. Right? You're within the normal range and that's all you care about. Are there other non-obvious signs that listeners should watch out for, or viewers I should say as well? What if we're tired all the time, or I've got a bunch of weird marks appearing on my skin.

I mean, is there some kind of obvious thing that we can see with our eyes? So let me just

Dr. Benjamin Bikman: reiterate the, the first point and revisit it just briefly. I would strongly encourage anyone who can to get their fasting insulin measured. So next time you go in actually for a lab test, try to buck the trend of insulin never being even discussed and say, Hey, can you check that box there and actually measure my insulin?

And if you can get a clinician to do that for you, you want to see your insulin somewhere below about six microunits [00:31:00] per mil. So if you see that lower number, single digits, that's a really, really good sign that you're insulin sensitive. If you aren't able to convince your clinician to measure insulin, then look at your lipid markers, take your triglycerides number and divide it by your HDL cholesterol number.

And if that ratio, the triglycerides divided by HDL is less than around 1.5, even better, less than one, that's a really good sign that you're insulin sensitive. And so your metabolic health is going to be somewhere good. If that number is down by close to one or even lower now, if you aren't relying on a blood test, then actually you mentioning the skin is a good one.

Skin is a window to the metabolic soul. And interestingly, you can see the two most common skin features right around the collar line of the neck. One of them is a condition called ssis. Nican, which is a term, a complicated term, referring to the skin changing in both texture and color. And with the color, it [00:32:00] simply starts to get a little darker pigmented.

And so the melanin expression starts to change a little bit and the skin gets a little darker. Now, depending on the ethnicity, it might be hard to tell if the skin is darker, as the skin may naturally be darker across ethnicities. But thankfully, that's where the other part of this comes in, which is that the skin also starts to take on the form of like a crinkled tissue paper.

So it's a very kind of wrinkled, deep, wrinkled, crinkled skin, and you can very much see that and feel it. So that's one skin condition. There's another one. Commonly called skin tags. It's like a teeny little column of skin just jutting right up. And people probably can, they know what I'm talking about.

They've seen it before, but it's these small little, well little mushroom stalks of skin. Um, and they're small, but you'll see them kind of dangling up like a, almost like a teeny little finger poking up outta the skin. And those are both, uh, very common manifestations of insulin resistance. Thankfully.

They're also ones that can go away quite quickly as the insulin resistance improves.

Jordan Harbinger: Yeah, [00:33:00] that's good to know. What was the, by the way, I'm looking at my blood work now. What was the two things you divide into one another? Triglycerides, and what was the other one?

Dr. Benjamin Bikman: Triglycerides divided by HDL.

Jordan Harbinger: Okay. So this is old blood work, but 40 divided by 60.

Dr. Benjamin Bikman: If that's below one and a half, that's great.

Jordan Harbinger: Lemme try this right now. 40 divided by 60. Point six six.

Dr. Benjamin Bikman: Oh yeah, you're laughing. That's great. Well

Jordan Harbinger: that makes me feel better. I wish I tested insulin.

Dr. Benjamin Bikman: That's a very, very good sign.

Jordan Harbinger: Yeah. Tell me about, and I'm sure you have a whole rant on this, but tell me about GLP one agonists, the AKA ozempic and stuff, because isn't this why people isn't insulin what this was originally four?

Dr. Benjamin Bikman: Yeah. So these, uh, semaglutide, which is the main drug that has been now labeled as Ozempic and wegovy, and there are a few other drugs, if anyone is wondering about the drug. If you are looking at a drug and it has the ending of glut tide or uti, it's gonna fall within this family of drugs, which is mimicking the actions of a hormone that we all make in our intestines called GLP one.

So we all make [00:34:00] GLP one. It's a hormone and it has beneficial effects for metabolic health. One effect is to help improve blood sugar. It's to help blood sugar control by telling the liver to hold on to glucose and not be releasing it into the blood. But as GLP one levels go up, there are these other effects that help with appetite.

One is that it will slow the movement of food through the intestines, so you just feel fuller for longer. And then second, complimenting that is that GLP one as a hormone will tell the brain, it will activate satiety centers in the brain. So the brain will be at that top level telling the body, Hey, we're not hungry.

We don't need to eat. So all those compliment each other quite well. So all of that was leveraged into these new drugs, like semaglutide being the main one. What's interesting is that while I, I have very strong reservations about the current use of these drugs, I believe they're used too readily for the wrong purpose and at too high of a dose.

And the purpose matters because when we talk about these drugs, we talk about them as weight [00:35:00] loss drugs. And that may give the person this mistaken view that as long as they're injecting, they're good to go and they don't need to worry about anything. I think that's the wrong way of looking at it, which leads to problems of people, um, having profound nausea and even depression and suicidality.

Those are all increased risks with the use of this drug, and I think it's because it's too much of a good thing. Now, if you'll allow me, let me kind of make a different use case for the drug. There was a paper published in 1996 which documented the GLP one response in humans to eating a high carbohydrate meal and a high fat meal, and they noticed differences and they looked at the subjects of the study based on whether they were lean or obese.

And when lean and obese people ate a high fat meal, the GLP one response was very similar. It had a lot of overlap. So one way of interpreting that would be to say that whether you're lean or obese, if you eat a high fat meal, you get a roughly equal degree [00:36:00] of satiety. In as much as GLP one is a satiety hormone, it makes us feel full, makes us want to eat less.

Then that is gonna be equal regardless of your body fan.

Jordan Harbinger: Can I guess the rest of this, please? So the fit people versus the obese people eating a high carb meal, the satiety was wildly different and the people who were obese were not satisfied after eating even a high carb meal.

Dr. Benjamin Bikman: Yeah, exactly. So in fact, there was literally Jordan, there was no response.

Oh wow. When they looked at the GLP one response to the high carb meal, it stayed within the normal range and it did not reach a point of statistical significance at all in the obese people. Whereas in the lean group, it went fantastically high and stayed elevated for about three hours. And so all of this is to say that we should have empathy that if we are sitting at a table and we're going out for pasta and garlic bread, someone is going to eat a certain amount of that and feel full in part because of GLP one.

Someone's going to eat a certain amount of that and not feel full and simply be looking around for the next plate of pasta and, [00:37:00] and garlic bread. Yeah. So to me that suggests a better way of using these drugs. Because if we can then say to the person, you have a carb problem, and let's face it, people who are overweight, obese, and diabetic, no one is sitting around craving a plate of bacon and eggs.

It doesn't happen. They're not wanting a stick of butter to be chomping on while they're watching a show on a Friday night. Oh, that's interesting.

Jordan Harbinger: Yeah.

Dr. Benjamin Bikman: They want carbs. Carbs are the one macronutrient that humans crave and dare I say, have addictive tendencies towards, based on many conventional definitions of addictive behavior.

They seek it, they crave it, they regret it. When they over, they can't moderate it is all these aspects of addiction. Yeah. So we say to them, let's give you this drug to help you learn to eat differently and have a different relationship with food, and we're gonna start it at a lower dose, what you could even call a microdose, and we're gonna put you on a 90 day cycle.

Remember, this isn't a [00:38:00] weight loss drug, so we frame it properly. We say this is a drug to help you control your carbohydrate cravings or addictions depending on the person. And then we check on them. We say, how are you doing? How are your carb cravings working? They're getting a little better. And as they start to learn to change their habits and learn what it feels like, 90 days is enough for many people to actually cure an addiction.

And so around at 90 days, let's wean them off. Let's cycle off the drug and let's see whether some of these habits have stuck. In some people they have, and I know this from just anecdotal evidence of people I know, sure. Other people, it sticks for a while, maybe a month or two, and then it starts to fade and their habits are returning and they're starting to gain weight again.

Then we say, alright, let's cycle you on again.

Jordan Harbinger: Is that in part because they didn't build habits, they were just injecting a weight loss drug and they were like, they didn't go to change their diet.

Dr. Benjamin Bikman: When it comes to addictions, I am admittedly a little outta my wheelhouse where I, I can't articulate necessarily the variables that might go into one person being able to change habits and one person not.

Jordan Harbinger: That's true.

Dr. Benjamin Bikman: But even still, [00:39:00] I think it's important that we frame the conversation outside the context of just weight loss and we say, this is a drug to help you change your habits and then the person is more mindful where in the evening, if they are now starting to crave uh, five bowls of cereal, they will remember, hold on, wait.

I'm taking this drug to help me control these carb cravings. And I think there's something to be said for that little bit of placebo kick where if they're thinking about the drug and the proper framework, I believe firmly that they're gonna get a little more help.

Jordan Harbinger: I'm glad you brought up the the satiety thing because it's really easy for people to kind of be mean to overweight folks and be like, you just need to try harder.

But I know from going on a diet and losing all that weight myself without drugs, I was talking to a bodybuilder who diets for contests. He was describing how hungry he was at certain calorie levels, and I was like, I don't really experience that. I'm a little hungry, but then I just hit my 1400 or I was at like 1300 calories for a while, which is ridiculous.

And he's like, and you didn't get [00:40:00] angry and you know, kick the dog and try to bash the door down and rip the refrigerator off its hinges. And I was like, no, I just went to sleep. And he's like, you have a superpower for controlling your hunger. It made me realize that like if I didn't have that, I just would've eaten chocolate covered Rice Krispies or whatever the heck we got in the pantry for here for the kids.

Until I hit my 2,500 calories or something, I would've busted my diet. And so any sort of drug that can help people change their habits, I think is fair. I wanna push back a little, um, a play devil's advocate maybe a little bit too. Even if you took GLP one forever, semaglutide whatever, forever, isn't that still healthier than being obese?

'cause does obesity look, reading your book? It just basically is one of the worst things that can ever happen to your body. So unless these drugs kill you in some other way, and even if they do, maybe it's kind of better to still live with that and then not be obese. 'cause like maybe you lost some bone and you lost some muscle and you need to work on that, but you don't have high blood pressure, you don't have joint pain, you don't have cardiac [00:41:00] issues or whatever.

You, you don't have social stigma that you're dealing with. You don't have confidence issues. You're dealing like, it kind of seems like even the worst GLP one ozempic addiction is better than being a hundred pounds overweight.

Dr. Benjamin Bikman: That's a really, really good counter. In fact, I, I, as a scientist, just to help everyone appreciate it, I'm one of those old fashioned scientists where I just pursue truth to be a, a good scientist and I hope I am one in all, in all humility.

I hope I am one. You have to be prepared to dump every theory you have, the moment the data proves you wrong. And so you have to be humble and open-minded to counter points. What would be the counter to that? So first of all, I don't know, in the absence of data, I can't say whether it would be better, but the data we do have are pretty clear.

And like if you tell someone, uh, you're gonna be on this drug for the rest of your life, it's telling that 70% of users of these drugs in the United States get off the drug of their own volition at two years. They don't want to keep taking it.

Jordan Harbinger: That's great. They

Dr. Benjamin Bikman: basically say, I'd rather be [00:42:00] fat.

Jordan Harbinger: Oh, nevermind.

I, I spoke too soon. I thought you meant it worked. Did they get off the drug? Not I'd rather be fat. No,

Dr. Benjamin Bikman: no. Well, I mean, maybe some people would say, well, I lost the weight I wanted, now I'm off. But they gain it all back within a year. That's very clear.

Jordan Harbinger: I see.

Dr. Benjamin Bikman: In fact, they end up fatter because of the muscle and bone loss, which will not come back.

The fat mass rebounds fantastically quickly. So 70% of users, they get off the drug at two years of their own choice. Now coincidentally, at that same two year period, a study was published just within the past few months, finding a 200% increased risk of major depression in these people that go on the drug compared to placebo.

A 100% increased risk of suicidal behavior. So there is something about these drugs where they would rather be fat than feel the way they're feeling and, and so maybe one way of articulating this, now this is my own opinion here. As much as we talk about these drugs as, and I don't even mean for this to sound like I'm [00:43:00] universally opposed, I hope I've articulated what I think is a use case for these drugs.

Yeah,

Jordan Harbinger: it doesn't sound like you are. So

Dr. Benjamin Bikman: one way of looking at the drug as much as we, we put a very favorable light on it by saying, this drug helps you control your cravings and you crave these carbohydrates less, maybe if we're being a little more honest, we would say, this drug makes you less interested in things you used to be interested in.

And a person was interested in carbohydrates and snacking on salty and crunchy and sweet and gooey foods, which is good to control, but they might have also been interested in going and playing pickleball with their friends. Yeah. Now they don't really care to do that as much as they used to. They might've been interested in getting together with the girlfriends and going on a walk around the block every evening, and they don't really do that anymore.

Maybe the more honest view is that this drug reduces your interest in in life and things that you used to be passionate about.

Jordan Harbinger: Yeah. That's scary. In fact, that totally jives with something I'd read about these a couple of months ago, which is that they might [00:44:00] have a role in treating certain addictions. I don't know if you've seen this data, but it was something like they were using GLP one antagonist for addiction, which totally makes sense if you look at carbs as an addiction and then you realize it makes people depressed because they're not as interested in other things they were interested in.

Well, heroin is one of those things. Or alcohol is one of those things, or Yep. I dunno. Cocaine. Yeah, exactly.

Dr. Benjamin Bikman: In fact, that that evidence is part of why I articulate the view the way I do. I see. I'm very familiar with the fact that it can be used to control addictions and that's why I think it works the way it does.

It makes you less interested in the foods you used to crave, but it also makes you less interested in the other things you used to enjoy.

Jordan Harbinger: Yeah, that's scary man. There's a lot, uh, more with insulin resistance than I'd love to cover and we're gonna blast through some of the stuff super fast. I, I think, but brain health was something I wasn't really expecting.

Memory learning insulin resistance in the brain. Uh, you even mentioned that Alzheimer's is sometimes called type three diabetes. Can you speak to that a little bit? Yeah, it

Dr. Benjamin Bikman: is. Yeah, but it, the, it's scary, but again, I would say there's some good news because I think there's something empowering about [00:45:00] realizing that so many of these scary chronic diseases have a metabolic core.

There's a good news there because the, you can do something about metabolic health rather than just feeling helpless as you descend in a cognitive decline. So the brain is no exception as every tissue in the body suffers in insulin resistance. Most people don't appreciate the fact that the brain, in order to get enough glucose to meet its energetic needs, it requires insulin to be working well.

And so as the brain tissue becomes insulin resistant, now insulin comes and knocks on the doors of these neurons asking the doors to open up so the glucose can come in to fuel the neuron. The doors don't open. There's no answer to insulin. And so as you improve insulin sensitivity, you enhance the brain's ability to get glucose.

Now, there's another part to it because as you also improve insulin sensitivity, your insulin levels come down, and as insulin comes down, the body starts burning more fat. And when the body burns more fat, it makes more of something called ketones. Mm, [00:46:00] I've heard of this. And ketones are a very favorable fuel for the brain.

The brain loves ketones to put it in a silly way. In fact, if the brain has a preference for either glucose or ketones, it chooses ketones. If it has equal access to both from the blood, like 70% of its energy will start coming from ketones. If the ketones are available, even when the ketones are at lower levels than the glucose, just evidence of how much the brain prefers ketones.

And when you give a cognitive decline, brain ketones, cognition improves. This has been now shown in multiple studies. Human studies where you take people with Alzheimer's disease, kick them into ketosis by say, some exogenous ketones, some ketone supplements. So rapidly get them into ketosis, have them repeat some cognitive tests and they'll do better.

Depression is one of the symptoms of Alzheimer's disease. It's not just memory, but it is all a manifestation of the brain starting to go hungry, where the brain starting to [00:47:00] starve because it can't get enough glucose because of insulin resistance and because people are spiking their insulin all the time, they're never making ketones.

So you want to give the brain a shot of ketones.

Jordan Harbinger: I know that insulin also affects testosterone sperm. There's erectile dysfunction ramifications here. I will say when my A1C slash insulin resistance, triglycerides, cholesterol, all that stuff went down and got healthier. My hormones went way up on their own.

And I read in your book this was a slap across the face for sure. Fat tissue in a way acts like an ovary in terms of aromatization and hormones. Can you tell us what that means? 'cause that was, man, if you told me that, I wouldn't have gotten fat in the first place, I think. Yeah,

Dr. Benjamin Bikman: yeah, yeah. No, I mean, you definitely start thinking of like a scene from Seinfeld where like the man's ear or the bro where the guys starting to store fat in a way that is less manly than it used to be.

You actually expressed the perfect term here. Aromatization is the term to refer to the actions of an enzyme called aromatase. And aromatase. Its purpose is to take [00:48:00] testosterone and convert it into estradiol, which is the main estrogen. Estrogen is actually a little family of hormones. It's not one single hormone, but it's a little known fact that all estrogens were once testosterone in males and females.

It's just ovaries do this more than testes do. One of the many, many unexpected effects of insulin is to inhibit aromatase. So as much as Aromatization is attempting to convert testosterone into estradiol in a man that's happening less than it, it is of course in female counterparts, but the bigger a man is getting.

The bigger his fat cells are getting, the more the fat cells actually are expressing this enzyme aromatase, this enzyme that you think is just one related to the gonads and sex hormone production and the testes and the ovaries absolutely begins to express itself at higher amounts and at ever greater activities in the fat cells of the person as they're getting fatter and fatter.

This is important though because it changes the perspective. We have a perspective, which is that you are [00:49:00] fat because you are low T. In fact, in most men, it's actually probably the exact opposite. You are low T because you have too much fat, and as you reduce your fat, you reduce the aromatization. And now your testes and all that hard earned testosterone they're making can remain as testosterone the way the testes intended it to be without the fat cell taking it in an hijacking it and sending it out as estradiol, making you less manly, literally physically.

So the more we cut back on fat cell mass and just fat mass, the more the testes are able to do the job they want to do, which is just fill the body with manly testosterone.

Jordan Harbinger: Interesting. Yeah, I, I love the way you put this. I think also erectile dysfunction. I, I get a lot of letters for our feedback Friday segment instead of advice segment.

I am quite disturbed by the number of 20, 25-year-old men who have erectile dysfunction. And at first I was like, stop watching so much porn, you know, if you can't get it up for your girlfriend. Amen. Amen. But that's a [00:50:00] gross over simplification probably. But look, I'm not gonna say that's not a problem because it's definitely a problem.

Dr. Benjamin Bikman: Agreed, agreed. No, I, I'm glad you noted that though. Yeah, because I do think it's an important part of our culture. Where the more we indulge in this kind of behavior and assume it doesn't have any consequences, the more ignorant we are and the more we're hurting these young men. They need to know that the more you're exposing yourself to pornography, the harder it's going to get for you to have a normal sexual relationship with a real human.

Jordan Harbinger: A hundred percent. From a science perspective, we're not evolved to have a thousand sexual partners at any point in our life. Uh, even, you know, Genge Khan probably had his own issues as a result from that. Right. Uh, but now like a guy who's in high school and has a phone can access a new virtual sexual partner every single day.

Dr. Benjamin Bikman: Oh, no, Jordan, it is sobering. It makes me ache for these young men.

Jordan Harbinger: Yeah.

Dr. Benjamin Bikman: I think about the risk of really sounding kind of weird, you know, growing up in a little farm town in Alberta. If you wanted to try to look at something inappropriate,

Jordan Harbinger: you gotta drive it down.

Dr. Benjamin Bikman: You literally couldn't find it in our little town.

We had [00:51:00] one little gas station. No dirty little magazines were sold there. Oh, I see. You literally couldn't find it. And now the idea of a young man having it in his phone, man, these boys have to have a level of discipline that we didn't need.

Jordan Harbinger: Yeah.

Dr. Benjamin Bikman: In the early, mid eighties, you know, when I would've been, or even late eighties when I would've been at my peak of curiosity of these kinds of things, late eighties, I guess, early nineties, I, I'm so grateful I didn't have access to it.

Jordan Harbinger: It's a good point. I got access to internet porn In what? Like college. And I was like, well, okay, but I also have a girlfriend, so like, you know, I is gonna choose the real one. But pornography aside, I get these letters from these guys that I think is part porn brain. Right. They can't get it up without porn or something like that.

But I also, I also think that they have other physical issues and it never occurred to me that it could be the fir, the canary in the coal mine of insulin resistance. Because of the hormone thing. Can you speak to how that might affect our manhood?

Dr. Benjamin Bikman: Absolutely. So we already touched on the testosterone aspect, and that does matter.

Testosterone is a relevant [00:52:00] part of normal erectile function in fertility in men, but we don't even need to go that far. We can actually just come right back to insulin resistance. It's a little known effect. One of insulin's additional effects is to act on the endothelium of blood vessels. The endothelium is the innermost lining of the blood vessels.

So think about every blood vessel as a hose, a tube. Now the innermost layer is the endothelium. When insulin comes to the endothelium and binds its own receptors on the endothelium, it'll stimulate the production of a molecule called nitric oxide. The nitric oxide will permeate through the blood vessel and tell the blood vessels to expand.

That's a process called vasodilation, and it is an essential part of normal erectile function that insulin acts in those blood vessels to stimulate this increased blood flow to enable normal erectile function. If insulin isn't working well in insulin resistance, it isn't, then those blood vessels stay constricted.

In fact, this is so well [00:53:00] known to be connected that there was a paper published by physicians maybe 10 or 15 years ago, and the title of it was really telling where it said something like, is erectile dysfunction the earliest manifestation of insulin resistance in otherwise healthy men? I think that might literally be the title of the manuscript, just suggesting that there's this incredibly relevant metabolic component to this hormone that we used to think of as only being relevant to blood sugar.

No. It also regulates even something like erectile function. And then in women, we have the balanced other side, which is polycystic ovary syndrome.

Jordan Harbinger: Uh, is that P-C-E-O-S-P-C-O-S-I keep hearing about this.

Dr. Benjamin Bikman: That's the most common form of infertility in women. And once again, it's a consequence of insulin resistance affecting the ovaries ability to produce sex hormones.

Wow. Which prevents her from having a normal ovulation cycle. And she has PCOS as a result. So both of the most common forms of infertility in men and women within their respective spheres still have the same metabolic [00:54:00] core.

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Now for the rest of my conversation with Dr. Benjamin BigMan, you cover in the book Air Pollution and Insulin Resistance, aging Cancer, even Lack of Sleep, making us insulin resistant or light exposure at night. It's kind of like all the stuff we kind of knew we had to do for some reason for health generally turns out to all kind of be connected to insulin.

It's really wild.

Dr. Benjamin Bikman: That's exactly right, and and this is why. When I attempted, like I, I mentioned moment, uh, a little while ago when I wanted to try to step out of academia and say, okay, do any of my ideas actually matter in the real world? Because if scientists are being honest with ourselves, [00:57:00] publishing a peer-reviewed paper in a scientific journal doesn't change the world.

It doesn't do anything.

Jordan Harbinger: No one will ever read it. Spoiler alert. Yeah. I was gonna say, nobody's reading it. Even my

Dr. Benjamin Bikman: own dad isn't gonna read those papers. Yeah. They're so irrelevant to the lay audience. So when I was first imagining what are my best ideas to articulate, to help people be healthier, it was to just bring awareness to this one problem because of how common it is and because of how relevant it is with so many diseases coming from it.

But just to be clear, I don't want someone to, to roll their eyes and think, okay, Ben believes that insulin resistance is the singular cause of all ills. No, there are other noxious stimuli that would play into chronic diseases that would totally be going around insulin resistance entirely. But if we know that so many of these chronic diseases do come from one single thing that is empowering, like I've said, because then we can just address that one single thing knowing that all these other things are gonna get better.

Jordan Harbinger: It was really sort of disgusting and eyeopening about the section of the book where you talked about how fat [00:58:00] cells essentially belch toxic stuff into your blood. Yeah. It's unfair. I There's your body betraying you. Right. They're, it's pumping out hormones you don't want, um, what, what was the other thing?

Cytokines. Cytokines or something. Yeah, exactly. What are those?

Dr. Benjamin Bikman: Yeah. Yeah. So cytokines are basically hormones that promote inflammation.

Jordan Harbinger: Okay.

Dr. Benjamin Bikman: And when the fat cells getting really, really big.

Jordan Harbinger: Yeah.

Dr. Benjamin Bikman: It's, that's why I said the smaller fat cells are anti-inflammatory. Not only because they're not releasing these pro-inflammatory hormones, but they're actually literally releasing hormones that dampen inflammation.

So they're turning it in the opposite favorable direction. But the bigger the fat cell gets, the more it is vomiting out these pro-inflammatory hormones that we call cytokines.

Jordan Harbinger: Once you read books like this, you're just like, oh my gosh, I had no idea how important it's to stay. Like you just think like, you get a little bit fat, it's not good for you.

Maybe it's a little bit extra pressure on your heart, your organs, and you're like, ah, I'll lose the weight later. You don't realize that having extra fat is just, you have fueled up an entire system of dangerous and [00:59:00] unhealthy hormones, chemicals, byproducts that is just 24 7 chugging into your body. It's like you might as well have a drip feed of diesel fuel into your right arm.

I mean, it may, it's not quite that bad, obviously, but it's just really scary to think about. 'cause again, you kind of think like, oh, I'm a little overweight, you know, whatever. What's the big deal? I'll lose it later. You don't realize it's doing damage every minute that you're alive.

Dr. Benjamin Bikman: It is a drip, in fact, that term, it's so well identified in obesity that they call it subclinical chronic inflammation.

It's subclinical because you're not coming in with some overt infection or you can't look at the person and say, boy, you have a lot of inflammation. And yet all of those levels are higher than normal. And so it is chronic. It's subclinical because it's not obviously causing clinical consequences, although it is subtly contributing to a, a host of them.

Jordan Harbinger: Once you're a diabetic, is it possible to get off insulin ever or It probably depends on the type of diabetes, right? If your pancreas doesn't work, I mean that's just

Dr. Benjamin Bikman: 100%. Depends. Yeah. Yeah. So if it's type one [01:00:00] diabetes where you don't have the beta cells that make insulin, then you're on insulin for life.

That doesn't mean there still isn't something to consider in all of this conversation. In fact, the same rule applies that if you are having to inject a lot of insulin to control all the carbs you're eating, the more you're injecting insulin, the more you have all the same consequences we've just been talking about, which is too much insulin driving insulin resistance and chronic disease.

So the same rule applies. You just can never get off insulin entirely. You always need some. Now in type two diabetes. That's absolutely the case that you can fully reverse the disorder. If it's true type two diabetes and not some form of type one to be clear, then you are always making insulin. It's just a matter of you've demanded too much insulin from your body for too long, and now you just need to recalibrate, if you will.

We published a paper a couple years ago with a local clinic where we took 11 individuals with newly diagnosed type two diabetes, every definition of type two diabetes they had, and within [01:01:00] just 90 days of a low carbohydrate diet, and mind you one that did not require them to count their calories, it was simply eat as much protein and fat as you want.

Just keep your carbs to this level per day. Count the grams of carbs you eat. So you don't have to be hungry. If you're hungry, eat, just focus on proteins and fats. Within 90 days, every single one of these 11 people had reversed their type two diabetes by every clinical marker. There was no evidence of the disease whatsoever.

Wow. Without ever having taken a single medication.

Jordan Harbinger: That's crazy. I mean, sample size 11 is what people are gonna say. So yeah, we need more. Yeah. So

Dr. Benjamin Bikman: we published it as a case study, but you're seeing larger SER case, um, reports and studies done more actual clinical studies done by groups like Virta, V-I-R-T-A.

Virta Health has really been on the forefront of expanding this practice of looking at things like type two diabetes and saying, this is a disease of you basically eating too much carbs.

Jordan Harbinger: Yeah. And

Dr. Benjamin Bikman: you just can't control your blood sugar anymore. And if you can't control your blood sugar, then let's just [01:02:00] eat less of it.

Jordan Harbinger: Wow. This is really interesting. But it's, it is great because what it means is you can take control of this and you might even be quite far gone down this road. You can still turn it back and reap all the benefits, especially to your brain and body. And again, it's part of your brain. Right. I think a lot of people might go, I don't care what I look like.

And now it's like, oh, if there's a lot more going on than what you look like you're gonna end up with. That's right. Alzheimer's or, yeah, Alzheimer's, dementia, other kinds of body issues that, you know, if you're in a penis isn't gonna work. Guys are like, wait a minute. Yeah, I want, I want that thing to work.

Yeah. Like I thought, okay, I'm overweight. At least I could take care of myself. Not for long there buddy. Not for long. You can't, yeah. It's not gonna work. Uh, it's not gonna work at all. Yeah. So get things going on here. Wow. This is quite powerful. I mean, just restricting your carbon intake is just from somebody who went on a major diet a few years ago, like I told you before.

If I only had to count my carbs that I could eat as much protein and fat as I wanted. That's an amazing diet. That's really not hard to do. It works because chiefly the calorie restriction is the issue. [01:03:00] Right. That's the part that makes you hungry. But if you can just eat chicken Yep. And you're good.

That's amazing. Yeah. Or even

Dr. Benjamin Bikman: hamburger.

Jordan Harbinger: Yeah.

Dr. Benjamin Bikman: Make some hamburger patties and eat those hamburger patties.

Jordan Harbinger: That's a diet that literally, I think anybody could follow.

Dr. Benjamin Bikman: The problem being how addicted to carbs are you? Yeah.

Jordan Harbinger: Right.

Dr. Benjamin Bikman: The concept is so simple, but the implementation might not be. There are some people who just with that knowledge are able to say, okay, I'm in.

I'm committed.

Jordan Harbinger: That was me. Yeah. You

Dr. Benjamin Bikman: might be one of those people.

Jordan Harbinger: Yeah.

Dr. Benjamin Bikman: But there are a lot of people we know where those carbs are calling. It's like a little siren call every evening. Tempting them to jump off the ship and drown themselves in.

Jordan Harbinger: Yeah. Like

Dr. Benjamin Bikman: a five bowls of cereal.

Jordan Harbinger: I mean that's when you gotta get out the atomic habits James Clear stuff.

Right. And like not have it in the house and like make it so that your DoorDash requires you to log in every time you wanna order something and you know all that, all that stuff to get rid of the carb temptations have a locking cupboard that your, if your wife wants to eat Cheetos, she can, but you can't get in there.

Yeah. But

Dr. Benjamin Bikman: also recruit help. Uh, you know, if you can mind you, sometimes the people we love end up sabotaging our [01:04:00] efforts. Yeah. 'cause they see you making a change that they don't wanna make yet or they're not prepared to. Right. But in so far as you can, like people listening who have a goal here, recruit help.

Ask your friend or family loved one, express some of these concerns and say, can you follow up with me? I've mentioned now a couple times having bowls of cereal that is like crack cocaine to me in the evening. I will go through this pattern of like an addict where I will say, well, I'm just gonna have one little bowl.

Fine. It's just not me knowing that I'm not gonna stop at one bowl. Yeah. If I could stop at one bowl, that would be fine, but I don't, I will not stop eating those frosted mini wheats until I have them coming out my nose.

Jordan Harbinger: Yep.

Dr. Benjamin Bikman: And so I've told my wife over the years, if you see me go to the pantry, but again, we don't buy it very often 'cause I know I can't control myself.

But if I, I'll tell her, Cheryl, if you see me going to the pantry, you stop me.

Jordan Harbinger: Yeah.

Dr. Benjamin Bikman: I'm gonna be a little tiffy about it. I'm gonna be a little angry. That's right. But I'm never mean. But don't care. You never care about how I feel about anything. Don't care now. Don't start now. So you're in charge. That's right.

You're in [01:05:00] charge. Yeah. You just tell me to stop. It has helped,

Jordan Harbinger: man. I'm the same way. If I, I'll be done eating, I'll be at my calorie thing. 'cause I still count the calories. I, I'm not the guy who can eyeball the food, even though it's just the, the numbers higher now. And I'm like, oh, there's Captain Crunch.

Yep. In the pantry. Oh man, I want a handful of that. So I take a handful and I'm like, yes, that's kind of a small handful. Let me get a bigger one. And then I, well, and I need a little milk just to help brush it down. Yeah. I don't, and you can't put that in your hand. So you put that in the bowl and you're like, that doesn't look like very much.

I could probably put another handful in there and then a little bit more milk. And then suddenly I'm eating a whole bowl of Captain Crunch at 9:30 PM and you're just like, how did I get here? I

Dr. Benjamin Bikman: know, I know. Like, that's what I mean. That's why I say it's like a true addict where, you know, you don't wanna do it.

But this is another reason why I rage against this mantra. Moderation in all things. And I think that's the thing that the dietician likes to say. Yeah. 'cause they don't wanna say that some foods are worse than others for some reason. I don't know what's in their brains that make them not able to admit that.

But moderation in all things is one of the most horrific [01:06:00] ideologies when it comes to addictive habits. Would we ever tell an alcoholic friend if we're going out for drinks, Hey, uh, just, we're gonna go out for drinks. Why are you drinking milk? And I say that as a Mormon boy who does drink milk. When I go out with buddies and we'll say, Hey, why are you drinking?

Why just come have a beer? Well, I can't. I'm an alcoholic. Well, then just have one.

Jordan Harbinger: Yeah.

Dr. Benjamin Bikman: How stupid is that? So Saint Augustine Funny for a Mormon boy like me to quote a Catholic Saint, Saint Augustine said, which is brilliant and beautifully articulated. Abstinence is easier than perfect. Moderation. For some of us, we need to acknowledge I'm an addict to these carbs, and so it's easier for me to never even start eating than it is to stop eating.

So just don't even start.

Jordan Harbinger: I routinely say, why did you buy the big box of this for the kids? And my wife's like for the kids. Huh? And I'm like, I don't need you. Enabling me. Yeah. No, but your dynamic might be the same as mine. Yeah.

Dr. Benjamin Bikman: My wife and I, I can have a pint of Ben and Jerry's, or a pint of Haagen-Dazs, one [01:07:00] for me and one for my wife.

She has this alien likability to pop the lid off and daintily, eat five or six bites, put the lid on and put it in the freezer. Can't relate. Yeah. I can't relate. Because not only am I gonna go to the bottom of my pint, but I'm gonna be wondering when she looks away so I can go finish hers too.

Jordan Harbinger: That's right.

I wanna just, I wanna taste a couple of those too on the other side. Yeah, exactly. Yes. So folks obviously should talk to their doctor before they go on diets of any kind probably. But yeah, lower slash cut out the carbs and stop buying 'em and things like that if you can, and see if your insulin, your fasting insulin levels change.

That's the metric we're looking at in the blood. Absolutely. What about artificial sweeteners? Like if I'm drinking a diet Coke, is this spiking my insulin and is that bad?

Dr. Benjamin Bikman: Yeah, good question. No, no. So it depends on the sweetener, but with Diet Coke, um, very explicitly, aspartame does not increase insulin.

And so drinking a diet soda, and even nowadays more and more of the sodas have sucralose in them too. So if it's a zero drink

Jordan Harbinger: Yeah. Um,

Dr. Benjamin Bikman: rather than just diet, then it has some aspartame and [01:08:00] sucralose. I personally don't like the taste of sucralose. It's a little too sweet for me. Yeah, same. So if I want an indulgence and I absolutely sometimes do, I will drink a diet Dr.

Pepper. And there was no effect on a CGM or on insulin whatsoever. Now, that's not to say all sweeteners are benign. Stevia is maybe the best one, most consistently. As long as Stevia has been around, there's like never been a single negative paper published about it. Aspartame is fine, Stevia is fine. Monk fruit extract is fine, erythritol is fine.

But then some of the other alls do have a mild insulin effect, which can have consequences where it might make you a little hungrier after. And so my view on sweeteners is if a person eats something that has been sweetened with a sweetener, and if it makes you a little hungry after then it's one you should probably avoid.

'cause it probably is spiking your insulin. And mind you, some people can have a different response based on their microbiome. The microbiome actually can metabolize some of these sweeteners in different ways. So it gets more [01:09:00] complicated than most people wanna think. But you know, I should have actually mentioned a sweetener, allulose.

Allulose is one that far from making you feel hungry, increases GLP one significantly. RX sugar for example, makes a bunch of Allulose products. You're gonna feel more full. Uh, so that's something I've used in the past. In the evenings when I have some cravings, I'll eat a little sweetened allulose bar or something and it, it'll be pretty effective for appetite control.

Jordan Harbinger: So not all

Dr. Benjamin Bikman: sweeteners are created equal.

Jordan Harbinger: You might have to send me a link to your favorite aose sweetened bar 'cause I've never heard of that. I wanna try that and I'll put it in the show notes. 'cause I think people are going, wait, there's a bar I can eat that will make me not want to eat more stuff after that.

That's pretty useful. What's one habit you changed after seeing your own data?

Dr. Benjamin Bikman: That's a great question. In fact, data's the right way to frame it because I did some of these changes I made based on data that I saw from wearables that I had on monitoring my sleep and at the same time monitoring my, my blood sugar levels with a continuous glucose monitor.

Maybe the one habit that I've changed that has helped me the most overall including, and most especially my [01:10:00] sleep habits, and I've long been a terrible sleeper, has been not spiking my blood glucose before I go to bed. Actually, I would wonder why I would be lying there in bed. My heart would be racing, it'd be beating hard and I'd be hot and like I'd sweat so much, I'd be so hot, and I didn't know that I was going to bed hyperglycemic every night.

And hyperglycemia actually stimulates the sympathetic nervous system. That's the aspect of our nervous system that gets us ready to run and engage in something physical. Well, that's a terrible time to inactivate your sympathetic nervous system when you're trying to sleep. And so the one habit I changed the most based on data my own was really avoiding glucose, spiking foods in the evening.

Easier said than done, but I've shifted to other habits.

Jordan Harbinger: Yeah. Mr. Cereal bowl. Exactly. That is easier said than done. Yep. It's funny. What? What's one thing you changed now? I stopped eating carbs in the evening. Didn't we just talk about how you eat [01:11:00] cereal every night? Yeah. That's good to know though.

Dr. Benjamin Bikman: But that helped me with my motivation, honestly.

That's good. Because when I started thinking about the lingering consequences of my poor sleep, it became a little more stark. Where before it would just be, Hey Ben, you're losing your six pack. You're gonna get a little chubby. Well, that's so subtle. Yeah. That I could justify it, but when I really acknowledged now this is making me really chronically sleep deprived and I feel miserable all the time.

Yeah. That gave me a little extra push to actually make, help me make some differences.

Jordan Harbinger: I'll wrap with this. If you could allocate, let's say, a hundred million dollars of NIH money tomorrow, what study would you run?

Dr. Benjamin Bikman: That's an awesome question. I would do the opposite of all of these weight loss studies. So there's still a very ongoing, raging debate about the nature of obesity.

Some people will say it's just purely calories. Some people will say, no, it's just purely hormones, namely insulin. And my view is that it's actually a little bit of both that a fat cell needs to be told to get fat, which is what insulin does, and it cannot without that signal. But at the same time, [01:12:00] it has to have those calories to fuel that growth.

So you can't have it either way. The problem is all the studies that have been done to try to answer that question, is it a calorie problem? Is it a hormone problem? Have been weight loss studies. Which introduces a tremendously relevant confounding variable, which is when you take the average person and say you're gonna go from your standard American diet to this low fat diet, high carb, it's actually still fewer carbs than it was compared to the standard American diet.

So in both diets, you actually have both lower calorie and lower insulin because even though this one over here is low fat, but high carb, it's still fewer carbs than it was before. 'cause you're making them eat so much less. So you've never been able to answer the question on any of these weight loss studies.

Is it a calorie problem or is it an insulin problem? So to answer the question better, we actually have to do a weight gain problem, which is try to make people fat. Have them on two different diets. Say, Hey, you're going on a high carb version of this high calorie diet. You're going on a [01:13:00] ketogenic version, a low carb, high fat version, but it's high calorie, and we're gonna see which one makes people fatter.

That then would answer the question much more definitively, and I would argue much more convincingly of what is it that makes us fat? Because trying to answer what makes us fat by doing weight loss studies is the wrong way to answer it, and it's gonna continue to lead to confusion. So we need to actually make people fat and see which one is harder to get fatter on.

Jordan Harbinger: That's a good point. I hadn't even thought about that. Wow. It seems like somebody would love to fund something like that. I don't know how the grant process works, but, oh man,

Dr. Benjamin Bikman: Jordan, it's so frustrating to get grants. It's maybe the one part about being a professor. I hate them as a scientist. I hate the most.

Jordan Harbinger: Yeah, I'm sure you're not alone. It is so difficult. It just seems like if we could figure out what don't, drug companies wanna know what makes people fat. Don't exercise. Companies want to know what makes people, it seems like a lot of people would be able to use these results

Dr. Benjamin Bikman: Well, yeah, but you say a drug company.

But the problem is there's no money to be made if it is just a matter of control your carbs.

Jordan Harbinger: I see. I

Dr. Benjamin Bikman: would argue that the fact that there's nothing to [01:14:00] patent is why these kinds of studies have not been done.

Jordan Harbinger: That totally makes sense. You're right. If the answer is, Hey, eat less junk, they're gonna go, well wait a minute.

I can't put a label on that. I can't sell that. Yep. To your insurance company. Yeah, you're right. You're kind of stuck. You're gonna have to raise that money yourself. The good news is it probably won't cost a hundred million dollars.

Dr. Benjamin Bikman: Oh, it'd be less.

Jordan Harbinger: Yeah.

Dr. Benjamin Bikman: Yeah. But more than I can fund at the moment. Yeah, someday.

Jordan Harbinger: Yeah, man. Gotta call those Walmart Mormons. See if they can cut you a check. You gotta start rallying

Dr. Benjamin Bikman: the big BYU alumni base.

Jordan Harbinger: That's right. Dr. BigMan, thank you so much. This is fascinating. I, you know, whenever I look at the nutrition stuff, I'm always like, oh, am I gonna be interested in this nutrition thing?

And then it's always just endlessly fascinating. I really enjoyed this conversation, man. Thank you so much.

Dr. Benjamin Bikman: Oh, I did too. This was great. Yeah. Thanks so much for having me on.

Jordan Harbinger: What happens when the only way to survive is to lie so well, you forget who you really are. FBI veteran Scott Payne went undercover with one of the most dangerous biker gangs in the country and almost didn't make it out.

JHS Clip: This is the way I was trained and this is what I think. Anytime you [01:15:00] or something that you're not to be something that's opposite of you. For a long period of time, especially in deep cover, generally one or two things is gonna happen. You're either gonna slip up and they're gonna catch you, or you're gonna become it because there's so many horror stories and undercovers, it sucks that the same mistakes are being made today that were being made in the eights.

You got a small department, you got somebody that's running the undercover, but that person is also the case agent who is going to get promoted if the case succeeds. I'm not saying people are gonna do the wrong thing. It's just a bad foundation, I guess people is kind of my business, even as an investigator.

At the end of the day, you need to be able to sit down with somebody and have a conversation with 'em and gather intelligence, get information, because if all else fails and computers shut down and phones and that's great. It's all good stuff, but it's all human intelligence and you just need to be able to talk to people.

You gotta be believable. And this is where a lot of people think about undercover and when I'm [01:16:00] out training and speaking, I mean, I'll ask, they're like, what do you think undercover is? Some people say acting. I go, okay, what else you think is lying? Pretend to be something you're not. The true definition of undercover work is you're forming relationships that you're most likely gonna betray.

That sucks if you look at it that way, but you need to be able to figure out a way. You're gonna do it and rationalize it in your mind so it doesn't have an adverse impact on you.

Jordan Harbinger: Go inside basement strip searches. A brotherhood built on betrayal and the psychological damage that still lingers on episode 1120 of the Jordan Harbinger show.

Man, there was a lot we didn't even get to. It's really more than just how fat you are. It's how you store it. How do we know if we have that DEXA scan, I suppose, you know, is it between my organs? Is it outside? Is it subcutaneous pants? Don't fit, can't see penis without mirror. I mean, good rules of thumb, but maybe not the best heuristic.

I've actually had people ask before if I had diabetes, because I am peeing constantly. I know some of you can relate. It turns out I'm just really [01:17:00] well hydrated. But if you also are not well hydrated and you pee constantly, check that insulin resistance. The book goes over a lot of other topics related to insulin resistance, autophagy, which is cell death, evolutionary context, early onset puberty, obesity, cancer, aging, air pollution, even lack of sleep can make us insulin resistant.

Basically, a lot of things that make us unwell. At first, at least lead to insulin resistance. It's really quite fascinating and alarming. So if you are insulin resistant, if that's what your blood work shows, I highly recommend getting that under control because man, the downstream effects from that are just as you heard in the show, a horrible, lethal insert adjective here.

Really not something you wanna face. All things Benjamin Bickman will be in the show notes on the website, advertisers Deals, discount Codes, ways to support this podcast, all at Jordan harbinger.com/deals. Please consider supporting those who support the show. Also, our newsletter, very engaged. You all are with this.

That was a weird way of Yoda, way of saying it. Anyway, the idea is to give you something specific and [01:18:00] practical that'll have an immediate impact on your decisions, your psychology, and your relationships in under two minutes. We make it a good fast read. It's out almost every Wednesday, and it's a great companion to the show.

Jordanharbinger.com/news is where you can find it. Don't forget about Six Minute Networking as well over at sixminutenetworking.com. I'm at Jordan Harbinger on Twitter and Instagram. You can also connect with me on LinkedIn in this show. It's created an association with PodcastOne. My team is Jen Harbinger, Jase Sanderson, Robert Fogarty, Tadas Sidlauskas, Ian Baird, and Gabriel Mizrahi.

Remember, we rise by lifting others the fee for the show As you share it with friends and you find something useful or interesting, the greatest compliment you can give us is to share the show with those you care about. If you know somebody who's interested in health, maybe is worried about their insulin, maybe needs to get in better shape, definitely share this episode with them.

In the meantime, I hope you apply what you hear on the show so you can live what you learn, and we'll see you next time. This episode is also sponsored in part by Progressive. You ever think about switching insurance companies to see if you could save some cash? Progressive makes it easy. Just drop [01:19:00] in some details about yourself and see if you're eligible to save some money.

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