Dave Asprey (@bulletproofexec) is a self-described biohacker, CEO and founder of Bulletproof 360, Inc., host of the Bulletproof Radio podcast, and author of Game Changers, Head Strong, and The Bulletproof Diet.

What We Discuss with Dave Asprey:

  • How Bulletproof founder Dave Asprey biohacked himself from a 300-pound heart attack waiting to happen to 9.6 percent body fat.
  • How a prenatal condition, bullying, a thyroid condition, and toxic mold collaborated to bring Dave’s health to a point so low even his doctor couldn’t help him.
  • What is your immune system’s “memory” forgetting, and what role does mitochondria play in how you feel?
  • What does Dave believe are the top two causes of autoimmunity, and what can we do to guard ourselves when our body can’t even identify the enemy?
  • Why does Dave put butter in his coffee instead of milk or cream like normal people, and what’s the difference between real Bulletproof coffee and what the small-town cafe on the other side of the world is trying to peddle as “Bulletproof” coffee?
  • And much more…

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Game Changers: What Leaders, Innovators, and Mavericks Do to Win at Life by Dave AspreyDave Asprey was a 300-pound multi-millionaire in his mid-20s on a collision course with a stroke or a heart attack — provided diabetes didn’t catch up to him first. He worked out 90 minutes a day for six days a week, ate a steady and reduced-calorie diet of whatever food medical professionals of the day prescribed as healthy, but he still couldn’t shed the weight.

So Dave fired his doctor and began “biohacking” as a way to take control of his own body. Through much trial and error, a voyage of renewal in the mountains of Tibet, and the loss of those aforementioned multi-millions, he dropped a hundred pounds, founded a company, hosts a podcast, and writes best-selling books like The Bulletproof Diet, Head Strong, and Game Changers. Listen, learn, and enjoy!

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Bulletproof founder Dave Asprey may not have invented the term “biohacking,” but he’s been responsible for adopting and popularizing its use to the extent that he appears under Merriam-Webster’s online definition of biohacker:

biohacker \ noun, plural biohackers
[Dave] Asprey, 42, is a self-described biohacker — somebody who uses science and technology to make his or her body function better and more efficiently. There are about 100,000 biohackers worldwide, Asprey estimates, and among them, he’s a celebrity.
Gordy Megroz

“The idea is you can change the environment around you and inside of you to get control of your own biology,” says Dave. “The first use of biohacking was in ‘92 [Ed. Note: Michael Schrage, “Playing God in Your Basement,” The Washington Post, January 31, 1988], but it was more about inserting jellyfish genes into your cat so it’ll glow and things like that.”

Dave’s interest in biohacking began not so much because he was fitness-minded and looking to find the upper limits of the human body’s capabilities, but because he was straining to climb his way out of the low place where years of neglect had left him. Dave was diagnosed with arthritis in his knees when he was 14, and he hit 300 scale-straining pounds by the time he was 23. Today, at 45, he weighs 203 pounds and is at 9.6 percent body fat.

“I’m sure a lot of that was inflammation, but I was a 46-inch waist; I’m a 33-inch waist now,” says Dave. “I’m actually lower than I was as a junior in high school.”

What catalyzed this dramatic attention to finally getting his health under control? As the co-founder of the company that hosted Google’s first server, Dave made $6 million by the time he was 26. But he also suffered from enough brain fog that he felt the need to buy disability insurance.

“It was terrifying, actually,” says Dave. “Also, my emotions would get all over the place. And then I said, ‘Something’s wrong. I’m going to just exercise. I’m going to lose the weight no matter what.’ I’d had a couple knee surgeries by then and I worked out an hour and a half, six days a week, and after a year and 18 months of that, I didn’t lose any weight. I could max all the machines and I realized I ate less than all my friends and I worked out more than all my friends and I [was] fatter than all my friends. I thought it was a moral failing. I should eat less lettuce leaves or something!

“What it was was I was eating the wrong stuff and there were environmental factors that [were] involved. I fired my doctor when he told me vitamin C would kill me and that maybe I should lose weight. When I told him what I did, he just looked at me like he knew I was lying!”

Diagnosed with high risk of stroke and heart attack as well as pre-diabetes, Dave was a computer programmer at the end of his rope — so he approached the problem from a hacker’s perspective. He stayed up all night reading medical research on PubMed and spent a considerable chunk of his $6 million fortune on anything he thought would help him lose weight and get his health under control before it was too late.

Listen to this episode in its entirety to learn more about the multitude of factors — common and uncommon — that contributed to Dave’s ill health, why Dave believes mitochondria are the key to slowing down the aging process, the sometimes misguided memory of the immune system and what we can do to point it in the right direction, why Dave puts butter in his coffee instead of milk or cream, the difference between real Bulletproof coffee and what the small-town cafe on the other side of the world is trying to peddle as “Bulletproof” coffee, the terrible thing Dave learned in business school about the value of a dollar, why getting stuck next to someone who bathed in olfactory-offending cologne can make you hangry (and what you can do to alleviate the problem), and much more.


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